Fluidized bed granulation, also known as boiling granulation, refers to a process in which powder materials are suspended and fluidized by air flow. Atomized binder solution is then sprayed into the fluidized powder bed to agglomerate fine powders into granules, followed by drying to obtain finished dry granules.
In practical granulation production, operators and researchers have summarized and analyzed the full lifecycle of fluidized bed granulation, and conducted various technical optimizations to continuously advance the development of fluidized bed granulation technologies. For instance, several primary factors affecting the quality of fluidized bed granulation were proposed and analyzed in early research. In recent years, driven by technological advancements, researchers have gradually introduced Process Analytical Technology (PAT) and mechanism modeling into fluidized bed granulation processes. The application of such technologies aims to mitigate the adverse impacts of process variables on granule quality, while enabling enhanced real-time process control and quality optimization for fluidized bed granulation.